Correlation of telomere length to malignancy potential in non‑melanoma skin cancers

Targeted Therapy in Nonmelanoma Skin Cancers

Nonmelanoma skin cancer (NMSC) is the most prevalent cancer in light-skinned populations, and includes mainly Basal Cell Carcinomas (BCC), representing around 75% of NMSC and Squamous Cell Carcinomas (SCC). The incidence of these tumors is continuously growing. It was found that the overall number of procedures for NMSC in US rose by 76%, from 1,158,298 in 1992 to 2,048,517 in 2006. Although mo...

No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer.

BACKGROUND Recent reports have shown that telomere length was associated with the risk of various cancers, but the results have been inconsistent. METHODS We prospectively evaluated the association of telomere length in peripheral blood leukocytes with the risk of skin squamous cell carcinoma (SCC) in 241 cases and 241 controls within the Health Professionals Follow-up Study (HPFS), and the r...

Primary malignancy in patients with nonmelanoma skin cancer-letter.

Photodynamic Therapy in the Management of Nonmelanoma Skin Cancers

Photodynamic therapy involves the use of light to activate a photosensitizer, localized in the diseased skin, resulting in the formation of cytotoxic reactive oxygen species. Topical photodynamic therapy (PDT) is used to treat nonmelanoma skin cancers, such as actinic keratoses, Bowen's disease, and basal cell carcinoma, superficial as well as nodular. This article presents up-to-date, practica...

Association of nonmelanoma skin cancer with second malignancy.

BACKGROUND Heightened risks of second cancers have been reported in patients with nonmelanoma cancer of the skin (NMSC), but this association has not been studied in a large, ethnically diverse, multigeographic population. METHODS This cross-sectional study assessed the association of NMSC with another malignancy in the Women's Health Initiative Observational Study, a study that was conducted...